[3] Wynwood has long been referred to as Little San Juan and is commonly known as El Barrio because many Puerto Ricans immigrated to this Miami neighborhood from the island and northeastern cities in the 1950s.

This brought renewed attention to the area, previously abandoned warehouses had begun to be occupied by artists, restaurants, cafés, and lounges.

According to the Walls' website, artists featured at Wynwood Walls include: René Mäkelä, Shepard Fairey, Okuda San Miguel, The London Police, Stelios Faitakis, Clare Rojas, The Date Farmers, avaf, ROA, Ron English, Jeff Soto, Logan Hicks, b., PHASE 2, Joe Grillo, COCO 144, Gaia, Vhils, Interesni Kazki, Brandon Opalka, Friends With You, DALeast, Faith 47, Santiago Rubino, Daze, Maya Hayuk and Lakwena.

[8] Wynwood has been a fashion hub since the 1920s when Jewish New Yorkers came to the neighborhood and opened factories to establish a thriving garment district.

With new job opportunities in this newly established Miami suburb, families began migrating from Puerto Rico to Wynwood in the 40s and 50s.

[citation needed] In 2010, the abandoned Wynwood Free Trade Zone at 2235 NW 5th Avenue was reconverted into a working production studio for films and television shows.

In July 2011, production plans were announced for the 2011 Charlie's Angels to be filmed in the old free trade zone building in Wynwood.

On August 1, 2016, the Centers for Disease Control and Prevention issued a travel warning, advising pregnant women not to visit the Wynwood, Design District and Midtown Miami areas.

Mosquito-control efforts in Wynwood have been difficult because it's a mixed-use area, where industrial sites are located next to a blend of residences and businesses.