Lodgepole Creek is a tributary of the South Platte River, approximately 278 miles (447 km) long,[2] in the U.S. states of Wyoming, Nebraska and Colorado.

As its name implies, Lodgepole Creek is a very small stream; for nearly all of its length it flows through the semiarid High Plains.

The Lodgepole Creek Valley has been a major transportation route for over 100 years; the line of the original transcontinental railroad, the Lincoln Highway/U.S.

According to a 1921 history of the Nebraska Panhandle, the first irrigation in that part of the state took place in the Lodgepole valley in 1871.

A dam was built across the creek at Fort Sidney and used to provide water for crops raised by the post's soldiers.