XXI Century National Medical Center (Spanish: Centro Médico Nacional Siglo XXI) is a hospital complex located in the Colonia Doctores neighborhood of Mexico City.

[2] The history of XXI Century National Medical Center can be divided in four stages.

[3] The first stage began in the late 1930s, which was the conception, planning and construction of the Centro Médico del Distrito Federal (Medical Center of the Federal District) belonging to the Secretaría de Salubridad y Asistencia (Ministry of Health and Assistance).

The third stage began in 1989, when several new or different buildings augmented or replaced the structures damaged or destroyed by the earthquake.

[3] The fourth stage began in 2004, when the four hospitals of the Center were categorized as Unidades Médicas de Alta Especialidad (High Specialized Medical Units).