It operates a pediatric critical care transport team including registered nurses, respiratory therapists, and physicians who transfer pediatric patients from smaller community hospitals to Yale New Haven Children's Hospital.

[4] In 2021, YNHH was ranked nationally in 8 of 15 specialties by U.S. News & World Report:[5] Psychiatry (#11); Geriatrics (#21); Diabetes and Endocrinology (#33); Pulmonology (#27); Neurology and Neurosurgery (#42); Kidney Disorders (#35); Gastroenterology (#45); Ear, Nose and Throat (#47); and Gynecology (#47).

A new 13-bed hospital opened in 1833 on seven and a half acres of land bordered by Cedar Street and Howard, Davenport, and Congress avenues.

The original building, called the State Hospital, was designed by prominent New Haven architect Ithiel Town and cost US$13,000.

In 1965, a more formal agreement with the Yale School of Medicine resulted in another name change to Yale–New Haven Hospital.

[9] In March 2003, The Wall Street Journal reported on the case of Quinton White, a retiree, whom the hospital had sued.

It had seized his bank account and put a lien on his house because White was in arrears in paying off his late wife's cancer treatment.

[10] Subsequent reporting indicated that the hospital had a practice of aggressively suing poor patients despite its status as a tax-exempt charitable organization.

Public protests ensued, and state attorney general Richard Blumenthal sued the hospital for keeping money that was intended to help poor patients.

[9] In response, the hospital forgave the debt of tens of thousands of patients, replaced its executives, and changed its billing practices.

The East Pavilion, originally called the Memorial Unit, was opened in 1952 (designed by Douglas Orr).

Located across the street from the inpatient pavilions, it occupies land that the original hospital was built on in 1833.

Construction on the new Yale–New Haven Cancer Hospital started on May 18, 2006, with the demolition of the Grace Building and site preparation.