The Yamazaki clan (山崎氏, Yamazaki-shi), a samurai and aristocratic clan in Japan, was a branch of the Uda Genji and the Sasaki clan and was elevated to the rank of daimyo by Toyotomi Hideyoshi in the Kamakura period.

Initially serving as the lord of Marugame Domain in Sanuki Province during the early Edo period, they were later deprived of their domain, with a branch remaining as a lower-ranking samurai family.

After the Meiji Restoration, they established the Nariwa Domain in Bitchū Province and were ennobled as a kazoku (baronial) family.

The clan were moved to Marugame Domain, Sanuki Province worth 50,000 goku.

The clan was later deprived of their position due to the lack of heirs in 1657 after the death of Yamazaki Haruyori.