The game is centered on a shadowy ex-Soviet figure named Yuri who has established a secret army of his own and poses a threat to the free will of the world.

In Command & Conquer: Yuri's Revenge, the story starts off assuming that the Allies were victorious in Red Alert 2.

The Allied commander is deployed to Los Angeles where Yuri is slaughtering the city's population, converting them to raw materials.

Following these victories, Yuri captures Albert Einstein, forcing him to work on his Psychic Dominator near the Great Pyramid in Egypt.

Wishing to bring the war against Yuri to a conclusion, the Allies and Soviets leaders meet in the Parliament Building in London to sign a peace and joint cooperation treaty.

Lieutenant Eva traces Yuri's mind-controlling transmission, exposing his home base on the Antarctic Peninsula.

A joint Soviet-Allied invasion is launched, eradicating the base and capturing Yuri, who is locked away in a Psychic Isolation Chamber, where he "won't be able to mind-control a fly".

In the new timeline, instead of Yuri, it is Carville himself who interrupts the emergency meeting at the White House, much to the shock of President Dugan.

Having mind-controlled the Allied forces there, he starts slaughtering its citizens for raw materials and building a Psychic Dominator.

To stop this, the Soviet forces infiltrate London and destroy a Psychic Beacon there, freeing the local Allied military from Yuri's mind control.

It is revealed to be a launch facility hosting a spacecraft programmed to fly to the Moon, which Yuri intends to use as a refuge when the Psychic Dominator network goes online.

Soviet Lieutenant Zofia interferes, causing Yuri to travel to the early Cretaceous with depleted power reserves.

Their new Robot Tanks are immune to mind control, and the Battle Fortress mobile bunker can crush enemy vehicles.

Their new Industrial Plant (which replaces Cloning Vats) which decreases the price and build time of vehicles, aircraft, ships, and (Soviet and Allied ore refineries) by 25%.

GameSpot said that "all its new features combine to make Yuri's Revenge ideal or even downright necessary for anyone who enjoyed Red Alert 2", and awarded 8.5 out of 10.

[7] The editors of PC Gamer US named Yuri's Revenge the best expansion pack of 2001, tied with Baldur's Gate II: Throne of Bhaal.