[5] This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA.

The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs.

Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA.

Alternatively spliced transcript variants encoding the same protein have been identified.

[8] This article incorporates text from the United States National Library of Medicine, which is in the public domain.