2E19693521417ENSG00000148516ENSMUSG00000024238P37275Q64318NM_030751NM_001323638NM_001323641NM_001323642NM_001323643NM_001323644NM_001323645NM_001323646NM_001323647NM_001323648NM_001323649NM_001323650NM_001323651NM_001323652NM_001323653NM_001323654NM_001323655NM_001323656NM_001323657NM_001323658NM_001323659NM_001323660NM_001323661NM_001323662NM_001323663NM_001323664NM_001323665NM_001323666NM_001323671NM_001323672NM_001323673NM_001323674NM_001323675NM_001323676NM_001323677NM_001323678NM_011546NM_001360981NM_001360982NP_001310567NP_001310570NP_001310571NP_001310572NP_001310573NP_001310574NP_001310575NP_001310576NP_001310577NP_001310578NP_001310579NP_001310580NP_001310581NP_001310582NP_001310583NP_001310584NP_001310585NP_001310586NP_001310587NP_001310588NP_001310589NP_001310590NP_001310591NP_001310592NP_001310593NP_001310594NP_001310595NP_001310600NP_001310601NP_001310602NP_001310603NP_001310604NP_001310605NP_001310606NP_001310607NP_110378NP_035676NP_001347910NP_001347911Zinc finger E-box-binding homeobox 1 is a protein that in humans is encoded by the ZEB1 gene.

[5][6][7] ZEB1 (previously known as TCF8) encodes a zinc finger and homeodomain transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site.

[7][6] ZEB1 and its mammalian paralog ZEB2 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors.

ZEB1 downregulates E-cadherin and induces epithelial to mesenchymal transition in breast and other carcinomas[9] A recent study suggested its contributing role in lung cancer invasiveness and metastasis development.

[10] Overexpression of ZEB1 has been identified as a potential risk factor for recurrence and poor prognosis in several types of cancers.