[6] ZEB2 (previously also known as SMADIP1, SIP1) and its mammalian paralog ZEB1 belongs to the Zeb family within the ZF (zinc finger) class of homeodomain transcription factors.

[5] The activation of TGFβ receptors brings about the phosphorylation of intracellular effector molecules, R-SMADs.

ZEB2 is also found in tissues that are not derived from the neural crest, including the wall of the digestive tract, kidneys, and skeletal muscles.

[9] Hirschsprung's disease also has many symptoms that can be explained by lack of ZEB2 during development of the digestive tract nerves.

[10] The risk of hepatocellular carcinoma and cirrhosis in chronic hepatitis B has been reported to be associated with a single-nucleotide polymorphism in the promoter region of ZEB2, designated rs3806475, under a recessive model of inheritance.