[5][6] ZNF238 is a gene that plays a major role in the "promotion of ordered and correctly timed neurogenesis leading to proper layer formation and cortical growth.

"[7] The loss of ZNF238 has been observed to cause microcephaly, agenesis of the corpus callosum, malformation of layers in the cerebral cortex, and cerebellar hypoplasia.

This new diversity has been observed to increase the invasiveness of the tumor, yielding proliferation into more areas of the brain than before the loss of ZNF238.

C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly.

[9] This article incorporates text from the United States National Library of Medicine, which is in the public domain.