ZNF730

[1] Zinc finger protein 730 is speculated to play a role in transcriptional regulation in acute myeloid leukemia and endometrial cancer.

This is because ZNF730 was found to be expressed in higher levels in endometrial cancerous tumor samples and has been reported as a core binding factor in acute myeloid leukemia.

The C2H2-type protein motifs can regulate transcription by recognizing and binding to DNA sequences.

[3] The human ZNF730 gene is 5533 nucleotides long and it encodes transcript variant 1 which is the longest isoform.

[1] Through an HPA-RNA sequencing analysis of 12 different human tissues, protein ZNF730 has been found in high levels within the testis.

[1] High expression in the testis is likely because of C2H2-zinc fingers playing a role in spermatogenesis, which occurs inside the seminiferous tubules.

[6] ZNF730 was also found to be expressed in high levels within the brain, lymph nodes, and placenta.

This double-zinc finger motif is specific to zinc-finger proteins, made up of three genes: LIN-11, Isl-1 and MEC-3.

[10][11] The human Zinc Finger Protein 730 has been predicted to be localized in the nucleus of the cell, due to its transcription factor role.

Annotated ZNF730 Conceptual Translation
Annotated ZNF730 Conceptual Translation
Human ZNF730 Isoform Table
Tertiary Protein Structure for Zinc Finger 730 annotated using iCN3D.
Orthologs of ZNF730 in Homo Sapiens sorted first by smallest MYA and second by sequence identity to human protein.
Paralogs of ZNF730 sorted by highest to lowest percent similarity to human ZNF730 protein sequence.
Corrected Sequence Divergence vs. Median Date of Divergence for Zinc Finger Protein 730.