[5] The human gene maps to chromosome 2 q32.1 and consists of 4 exons that code for a protein of 1210 amino acids (137 kDa).

For example, Carl Pabo and his colleagues in 1991 discovered that mouse transcription factor Zif268 binds DNA using three linked C2H2 zinc fingers.

[11] From family, twin, and adoption studies, schizophrenia is found to have heritability of ~80%[7] and it is suspected that risk results from multiple genetic variants of small effect.

[11] The same SNP has been reported to correlate with slightly disturbed functional coupling of several brain regions in healthy persons, resembling the changes described in schizophrenia.

Moreover, the study showed that SNPs rs1021042 and rs359895 are associated with schizophrenia in Han Chinese patients, and that the rs359895 allele increases the promoter activity of ZNF804A.