The BUAP has a Regional Section there, which offers degrees in law, business administration and psychology.
The city is surrounded by three mountains: "Tres cabezas" (Three Heads), "Gran poder de Dios" (Great Power of God) and the "Apaxtepec", an extinct volcano.
Zacapoaxtla had its first, rustic, church in 1576 under the advocacy of Saint Peter that was later substituted by another during the first half of the 17th century.
The village obtained the category of town on 11 March 1826, after the end of the Mexican War of Independence.
In 1864, General Fernando María Ortega, governor of the state of Puebla, declared the Town of Zacapoaxtla "La ciudad del 25 de abril" ("The City of 25 April") as a memorial to these events.