Zalabiye (Arabic: زلبيّة) is an archaeological site on the left bank of the Euphrates in Deir ez-Zor Governorate, Syria.

The site is located near a narrow gap in the Euphrates Valley that is created by basalt outcrops and that is called al-khanuqa, or "the strangler".

Zalabiye was built during the third century CE when the short-lived Palmyrene Empire, centred on the oasis-city of Palmyra, extended its reach toward the Euphrates area.

The fortifications of the site were subsequently improved under the Byzantine Emperor Justinian I (527–565) as part of his program to strengthen the eastern border of the empire.

Approximately 1 kilometre (0.62 mi) upstream from Zalabiye, a dam had been built in the Euphrates with a diversion canal on the river's right bank.