This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus.

This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase.

Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL)[5] and physiological roles have been identified in mouse Natural Killer T cells[6][7] and gamma-delta T cells.

[8] Alternate transcriptional splice variants have been characterized in human.

[9][10] Zinc finger and BTB domain-containing protein 16 has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.