East of 170 Street the road passes by the Mayfield Common strip mall, and through some mixed residential-commercial areas.

East of 142 Street, Stony Plain Road branches northwest while the main roadway continues as 102 Avenue towards downtown.

After crossing 121 Street, the road's name changes to 104 Avenue which passes in front of the old Molson's brewery.

Prior to 1989, 104 Avenue formed the south boundary of the Old Canadian National rail yard.

Continuing east, 104 Avenue passes the 104 Street Promenade in Edmonton's warehouse district, and Rogers Place.

Prior to flying over Groat Road, it passes by Government House and the former site of the Royal Alberta Museum.