The 1921 Minneapolis Marines season was their inaugural season in the young American Professional Football Association (APFA).
The following individuals saw action in at least one game for the Minneapolis Marines during the 1921 season.
[19] The number of 1921 NFL game appearances is listed for each in parentheses.
There were no future members of the Pro Football Hall of Fame on the 1921 Marines roster.
Team captain and star was quarterback Rube Ursella.