The 1921 Rochester Jeffersons season was their second completed in the young American Professional Football Association (APFA), soon to be renamed the National Football League.
[2] The Union Quakers were able to arrange a game with Rochester to make up for the loss of a game between the Quakers and the Canton Bulldogs.
The Jeffersons played the Quakers to a 3–3 tie.
Since the Jeffs were losing large amounts of money during the 1921 season and needed the revenue from the Union Quakers game, the APFA decided to not interfere.
[3] This article relating to an American football season is a stub.