The 1991–92 Oklahoma State Cowboys basketball team represented Oklahoma State University as a member of the Big Eight Conference during the 1991–92 NCAA Division I men's basketball season.
The team was led by second-year head coach Eddie Sutton and played their home games at Gallagher-Iba Arena.
Oklahoma State received an at-large bid to the NCAA tournament as No.
After defeating Georgia Southern in the opening round, the Cowboys defeated Tulane to reach the Sweet Sixteen.
The run ended in the Southeast regional semifinal, as Michigan defeated OSU 75–72.