The 1998–99 Duke Blue Devils women's basketball team represented Duke University during the 1998–99 NCAA Division I women's basketball season.

Returning as head coach was Gail Goestenkors for her 7th season at the school.

The team played its home games at Cameron Indoor Stadium in Durham, North Carolina as members of the Atlantic Coast Conference.

3 seed in the East region, the Blue Devils reached the first Final Four in program history.

Roster Source[3] ^Coaches did not release a Week 2 poll.