The 2024–25 Duke Blue Devils women's basketball team represents Duke University during the 2024–25 NCAA Division I women's basketball season.

The Blue Devils are led by fifth-year head coach Kara Lawson and play their home games at Cameron Indoor Stadium in Durham, North Carolina as members of the Atlantic Coast Conference.

The Blue Devils finished the season 22–12 overall and 11–7 in ACC play to finish in a tie for seventh place.

As the seventh seed in the ACC tournament, they defeated tenth seed Georgia Tech in the Second Round before losing to NC State in the Quarterfinals.

They received and at-large bid to the NCAA Tournament, marking the second straight year the Blue Devils qualified for the tournament.