The 2021–22 Duke Blue Devils women's basketball team represented Duke University during the 2021–22 NCAA Division I women's basketball season.

The Blue Devils were led by second year head coach Kara Lawson and played their home games at Cameron Indoor Stadium in Durham, North Carolina as members of the Atlantic Coast Conference.

They were not invited to the NCAA tournament or the WNIT despite being ranked as high as No.

On December 25, 2020, it was announced that the team would end their season due to COVID-19 concerns.

[1][2] The Blue Devils finished the season 3–1, and 0–1 in ACC play.