2-Furonitrile is a colorless derivative of furan possessing a nitrile group.

Industrial synthesis is based on the vapor phase ammoxidation of furfural with ammonia over bismuth molybdate catalyst at 440-480 °C.

[3] Numerous laboratory methods also exist; for the instance oxidative dehydration of furfural with ammonia salts using hypervalent iodine reagents[4] or n-bromosuccinimide.

[5] From furfural aldoxime (with thionyl chloride-benzotriazole,[6] triphenylphosphine-iodine reagents,[7] or heating in DMSO[8]) and furoic acid amide (flash vacuum pyrolysis).

[9] 2-Furonitrile currently has no major applications but it is used as an intermediate in pharmaceutical and fine chemical synthesis.