Vardar were the defending champions, having won their fifth title.
The 2007–08 champions were Rabotnichki Kometal who won their first title.
The draw was held on 17 October 2007 in Skopje.
The first legs were played on 23 and 24 October and second on 6 and 7 November 2007.
The draw was held on 17 November 2007 in Skopje.