After a 5–1 beginning to the season, starting quarterback Trent Edwards suffered a concussion in week 5 at Arizona after an Adrian Wilson hit.
Leodis McKelvin was named to the Sporting News All-NFL team in his rookie year; he became a dynamic kick- and punt-return specialist.
[2] Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve One regular season home game per year will be played at the Rogers Centre in Toronto, Ontario as part of a five-year deal.
Appearing to attempt a 32-yard field goal, holder Brian Moorman completed a 19-yard touchdown pass to defensive end Ryan Denney.
Buffalo rallied as QB Trent Edwards completed a 7-yard TD pass to rookie WR James Hardy, along with Lindell's yard field goal.
In the first quarter, Buffalo trailed early as Cardinals QB Kurt Warner completed a 2-yard TD pass to WR Larry Fitzgerald.
Buffalo answered with Losman's 1-yard TD run, yet Arizona closed out the half with kicker Neil Rackers getting a 47-yard field goal.
In the third quarter, the Bills tried to catch up as kicker Rian Lindell got a 48-yard field goal, but the Cardinals answered with Warner completing a 2-yard TD pass to Fitzgerald.
In the fourth quarter, Arizona pulled away as Rackers nailed a 38-yard field goal, along with Hightower getting a 2-yard TD run, With the loss, Buffalo went into their bye week at 4–1.
QB Trent Edwards (3/3 for 18 yards), who originally started, was knocked out the game on the Bills' third offensive play by Cardinals safety Adrian Wilson with a concussion.
In the second quarter, the Bills regained the lead with QB Trent Edwards (fully recovered from his concussion) completing a 2-yard TD pass to WR Lee Evans, along with Lindell getting a 27-yard field goal.
A power outage at Ralph Wilson Stadium, caused by three helium balloons coming in contact with a transformer, led to portions of the game not being televised.
In the first quarter, Buffalo trailed early as Dolphins QB Chad Pennington completed a 2-yard TD pass to TE Anthony Fasano.
However, Miami began to respond as kicker Dan Carpenter got a 43-yard field goal, while RB Ricky Williams got a 3-yard TD run.
Buffalo responded with kicker Rian Lindell getting a 53-yard field goal, but the Jets replied with RB Thomas Jones getting a 7-yard TD run.
Buffalo ended the game with QB Trent Edwards completing a 14-yard TD pass to rookie WR James Hardy.
at Ralph Wilson Stadium, Orchard Park, New York Trying to snap a three-game losing streak, the Bills went home for a Week 11 MNF duel with the Cleveland Browns.
The Bills answered as Edwards completed an 18-yard TD pass to RB Marshawn Lynch, along with kicker Rian Lindell getting a 26-yard field goal.
In the first quarter, Buffalo trailed early as Chiefs QB Tyler Thigpen completed a 36-yard TD pass to RB Jamaal Charles.
Buffalo regained the lead as Lindell got a 39-yard field goal, while rookie CB Leodis McKelvin returned an interception 64 yards for a touchdown.
The Chiefs tried to come back as QB Quinn Gray completed a 3-yard TD pass to WR Dwayne Bowe, yet the Bills' lead was too much for Kansas City to overcome.
[1] at Ralph Wilson Stadium, Orchard Park, New York Coming off a road win over the Chiefs, the Bills went home for a Week 13 interconference duel against the San Francisco 49ers.
In the first quarter, Buffalo trailed early as 49ers QB Shaun Hill completed a 12-yard TD pass to WR Isaac Bruce.
In the third quarter, Buffalo tried to rally as kicker Rian Lindell nailed a 22-yard field goal, but the team struggled offensively for the rest of the game.
In the first quarter, Buffalo trailed early as Dolphins QB Chad Pennington completed a 20-yard TD pass to TE Anthony Fasano.
The Bills responded with a 34-yard field goal from kicker Rian Lindell, but New York answered with quarterback Brett Favre completing an 11-yard touchdown pass to wide receiver Jerricho Cotchery.
However, the Jets prevailed as safety Abram Elam forced a fumble, allowing DE Shaun Ellis to return the ball 11 yards for a touchdown.
Buffalo trailed early in the first quarter as Broncos quarterback Jay Cutler got a 2-yard touchdown run, followed by kicker Matt Prater getting a 23-yard field goal.
The Bills struck right back in the fourth quarter as quarterback Trent Edwards completed a 3-yard touchdown pass to rookie wide receiver Stevie Johnson.
at Ralph Wilson Stadium, Orchard Park, New York Coming off their road win over the Broncos, the Bills closed out their season at home with a Week 17 AFC East rematch with the New England Patriots.