Entering Week 15, the Broncos had an 8–5 record, three games ahead of the San Diego Chargers for the AFC West division title.
On February 29, 2008, LB Ian Gold and WR Javon Walker were released by the Broncos in preparation for the NFL Draft and free agency.
In the second quarter, the Broncos continued their domination as kicker Matt Prater got a 26-yard field goal, while FB Michael Pittman got a 3-yard TD run.
In the third quarter, Denver ran away with the game as Cutler completed a 48-yard TD pass to WR Darrell Jackson, while Prater nailed a 43-yard field goal.
In the fourth quarter, the Raiders spoiled the Broncos' bid for a shutout as QB JaMarcus Russell completed an 8-yard TD pass to WR Ashley Lelie.
With the dominating win, the Broncos began their season at 1–0; with the rest of the division suffering losses, Denver, in Week 1, is in sole possession of 1st place.
at Invesco Field at Mile High, Denver Coming off their dominating divisional road win over the Raiders, the Broncos played their Week 2 home opener against the AFC West foe, the San Diego Chargers.
San Diego immediately responded with RB Darren Sproles returning the kickoff 103 yards for a touchdown, yet the Broncos replied with rookie kicker Matt Prater getting a 52-yard field goal.
In the third quarter, San Diego started to rally as Rivers completed a 15-yard TD pass to Chambers, and Kaeding kicked a 21-yard field goal.
at Invesco Field at Mile High, Denver Coming off their last-second win over the Chargers, the Broncos stayed at home, donned their alternate uniforms, and played a Week 3 interconference duel with the New Orleans Saints.
The Saints answered with kicker Martín Gramática getting a 43-yard field goal, yet Denver replied with Cutler completing a 35-yard TD pass to WR Brandon Marshall.
The Saints answered with QB Drew Brees completing a 6-yard TD pass to Bush, yet Denver responded with Prater nailing a 34-yard field goal.
After recovering an Eddie Royal fumble early on Denver's next drive, Kansas City again failed to make it to the end zone and a 21-yard field goal by Novak put the Chiefs up 6–0.
at Invesco Field at Mile High, Denver Hoping to rebound from their divisional road loss to the Chiefs, the Broncos went home for a Week 5 interconference duel with the Tampa Bay Buccaneers.
at Invesco Field at Mile High, Denver Coming off their win over the Buccaneers, the Broncos stayed at home for a Week 6 duel with the Jacksonville Jaguars.
The Broncos tried to catch up as kicker Matt Prater got a 39-yard field goal, yet the Jaguars answered with QB David Garrard completing a 30-yard TD pass to TE Marcedes Lewis.
In the fourth quarter, Denver tried to come back as Cutler completed an 11-yard TD pass to TE Daniel Graham, but Jacksonville's defense stiffened, preventing any further scoring opportunities.
In the fourth quarter, Denver avoided a shutout loss as QB Jay Cutler completing a 10-yard TD pass to former Patriots TE Daniel Graham.
In the first quarter, Denver trailed early as Dolphins kicker Dan Carpenter got a 45-yard and a 47-yard field goal, along with CB Will Allen returning an interception 32 yards for a touchdown.
at Invesco Field at Mile High, Denver Coming off their road win over the Falcons, the Broncos went home for a Week 12 AFC West rematch with the Oakland Raiders.
The Broncos responded with kicker Matt Prater getting a 44-yard field goal, yet the Raiders got the halftime lead as WR Johnnie Lee Higgins returned a punt 89 yards for a touchdown.
The Broncos answered with QB Jay Cutler completing a 59-yard TD pass to rookie WR Eddie Royal, along with kicker Matt Prater getting a 25-yard field goal.
at Invesco Field at Mile High, Denver, Colorado Fresh off their road win over the Jets, the Broncos went home, donned their alternate uniforms again, and played a Week 14 AFC West rematch with the Kansas City Chiefs.
Denver trailed early in the first quarter as Chiefs kicker Connor Barth made a 26-yard field goal, along with CB Maurice Leggett returning an interception 27 yards for a touchdown.
Carolina soon responded with QB Jake Delhomme completing a 15-yard TD pass to WR Steve Smith, yet Denver answered with kicker Matt Prater nailing a 43-yard field goal.
In the second quarter, Carolina took the lead with rookie RB Jonathan Stewart getting a 2-yard TD run, while Kasay closed out the half with a 44-yard field goal.
at Invesco Field at Mile High, Denver, Colorado Hoping to rebound from their road loss to the Panthers, the Broncos went home for a Week 16 duel with the Buffalo Bills.
Denver stormed out to an early first-quarter lead as quarterback Jay Cutler got a 2-yard touchdown run, while kicker Matt Prater got a 23-yard field goal.
In the fourth quarter, the Bills answered with quarterback Trent Edwards completing a 3-yard touchdown pass to wide receiver Stevie Johnson.
Denver tried to come back in the fourth quarter as quarterback Jay Cutler completed a 25-yard touchdown pass to tight end Tony Scheffler and ran into the endzone for the 2-point conversion.