The 2009–10 South Carolina Gamecocks women's basketball team represented the University of South Carolina in the 2009–10 NCAA Division I women's basketball season.

The Gamecocks were coached by Dawn Staley, in her second year, and played their home games at Colonial Life Arena.

Gamecock freshman and future WNBA player Kelsey Bone became the first South Carolina player to be named SEC Newcomer of the Year, before then transferring to Texas A&M.

[1] South Carolina finished the season with a final record of 14–15.

[2] This remains South Carolina's last season with a losing record.