The Gamecocks, led by tenth year head coach Dawn Staley, played their home games at the Colonial Life Arena and were members of the Southeastern Conference.

They defeated North Carolina A&T and Virginia in the first and second rounds, Buffalo in the sweet sixteen before losing to Connecticut in the elite eight.

Heading into the NCAA tournament South Carolina was the #1 seed in the Stockton regional, where they defeated UNC Asheville, Arizona State, Quinnipiac, and Florida State, to win the Stockton region and get to the Final Four.

On April 2, 2017, South Carolina defeated Mississippi State to win their first national championship.

A'ja Wilson won the NCAA basketball tournament Most Outstanding Player award.