The 2020–21 South Carolina Gamecocks women's basketball team represented the University of South Carolina during the 2020–21 NCAA Division I women's basketball season.

The Gamecocks, led by thirteenth-year head coach Dawn Staley, played their home games at Colonial Life Arena and competed as members of the Southeastern Conference (SEC).

They finished the season 26–5 (14–2 SEC), won the SEC tournament, and won a bid to the NCAA tournament where they advanced to the Final Four and lost to Stanford.

The Gamecocks therefore received an automatic bid to the 2020 NCAA Division I women's basketball tournament, however the tournament was not held due to the COVID-19 pandemic, and were de facto named mythical national championship by finishing first in the major wire service polls, the AP Poll and Coaches Poll.

On December 31, 2020, during the Florida game, the program raised a banner to recognise the claim.