Less than a week after winning the Champions League, on 28 May, Inter manager José Mourinho left the club and joined Real Madrid.

[1] On the 10 June, Inter signed Rafael Benítez from Liverpool on a two-year contract, ending a six-year stint as manager of the English side.

[2] During the summer transfer window, Inter signed Luca Castellazzi from Sampdoria, and also bought the entire rights to Jonathan Biabiany from Parma.

Inter sold Ricardo Quaresma to Beşiktaş and Mario Balotelli to Manchester City, as well as also sold half of the rights to Rene Krhin to Bologna, Andrea Mei to Piacenza, and sent on one-year loan Vid Belec to Crotone, Victor Obinna to West Ham United and Andrea Ranocchia to Genoa after brought the half of his contract.

The Netherlands, including Wesley Sneijder, reached and lost the final match of the tournament against Spain after extra time.

[3] After this win, however, on 23 December, due to his poor performance in Serie A and separated by 13 points from the leader Milan, Inter announced on its website the departure of Rafael Benítez[4] to be replaced by Leonardo the following day.

Due to the long-term injury of Walter Samuel, Inter bought the remainder of Andrea Ranocchia's contract from Genoa[6] to become Leonardo's first signing.

On 15 March, Inter had a memorable 3–2 Champions League away victory over Bayern Munich at the Allianz Arena in the round of 16 after losing the first leg at home, but lost in the quarter-finals against Schalke 04.