Società Sportiva Calcio Napoli's 2010–11 season was its 68th in Serie A, and fourth consecutive year in the top flight.

Following the end of the World Cup, Napoli bought Edinson Cavani from fellow Southern club Palermo.

[4] Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Napoli were drawn against Swedish side IF Elfsborg of the Allsvenskan, who advanced through defeats of FC Iskra-Stal and FK Teteks in the previous qualifying rounds.

Hosting the first leg at the Stadio San Paolo, Napoli survived on a clear-path goal by Ezequiel Lavezzi in first half stoppage time, taking a 1-0 lead to Sweden.