The 2010 season was the Baltimore Ravens' 15th in the National Football League (NFL), their 13th playing home games at M&T Bank Stadium and their third under head coach John Harbaugh.

Hoping to maintain their winning streak the Ravens flew to Paul Brown Stadium for an AFC North rivalry match against the Bengals.

In the 1st quarter the Ravens trailed early when kicker Phil Dawson made a 28-yard field goal, but got the lead back after QB Joe Flacco found WR Anquan Boldin on an 8 and a 12-yard TD pass.

Then the Ravens replied and took the lead when Flacco made a 27-yard TD pass to WR Anquan Boldin, followed by kicker Billy Cundiff nailing a 49-yard field goal.

Fortunately, Baltimore was able to go back ahead as quarterback Joe Flacco completed an 18-yard touchdown pass to wide receiver T. J. Houshmandzadeh with 32 seconds remaining in regulation.

Middle linebacker Ray Lewis intercepted Pittsburgh backup quarterback Charlie Batch on the Steelers' final possession to end the game.

The Broncos replied with kicker Matt Prater hitting a 38-yard field goal, but RB Willis McGahee got a 30-yard TD run to put the Ravens ahead 31–10.

In the 1st quarter the Ravens got the early lead as kicker Billy Cundiff got a 26-yard field goal, but fell behind with RB BenJarvus Green-Ellis making a 2-yard TD run.

But they trailed with QB Ryan Fitzpatrick completing a 33-yard TD pass to WR Lee Evans, followed by kicker Rian Lindell hitting a 21-yard field goal.

In overtime, the Buffalo offense was driving in their own territory when after catching a pass, Ray Lewis stripped the ball from the receiver before he was down on contact.

A few plays later, including a 5-yard penalty, Cundiff successfully put the game away a 38-yard field goal to give the Ravens the win.

Coming off their home win over the Dolphins, the Ravens flew to the Georgia Dome for a Week 10 interconference duel with the throwback-cladded Atlanta Falcons on Thursday night.

Atlanta added onto their lead in the third quarter with Bryant's 51-yard field goal, yet the Ravens answered with quarterback Joe Flacco found wide receiver Anquan Boldin on a 5-yard touchdown pass.

The Falcons struck back in the fourth quarter as Ryan completed a 4-yard touchdown pass to wide receiver Roddy White.

However, the Ravens were considered favorites going into the game, given that they had never lost at home during the season, and all Tampa Bay wins were against teams with losing records.

Tampa Bay later tied it, but Baltimore scored two touchdowns, including one on a 65-yard pass from Todd Heap, to have a 17–3 halftime lead.

Coming off their win over the Buccaneers, the Ravens stayed at home for a Week 13 AFC North rematch with the Pittsburgh Steelers on Sunday night.

Baltimore delivered the game's opening strike in the first quarter as quarterback Joe Flacco found wide receiver Anquan Boldin on a 14-yard touchdown pass.

In the final minutes of the game, the Ravens were driving, trying to run down the clock, when Troy Polamalu sacked Flacco, forcing a fumble in the process.

Hoping to rebound from their loss to the Steelers, the Ravens flew to Reliant Stadium for a Week 14 Monday night duel with the Houston Texans.

The Ravens added onto their lead in the second quarter as quarterback Joe Flacco found wide receiver Derrick Mason on a 9-yard and a 26-yard touchdown pass.

The Saints tied it in the fourth quarter on a 15-yard touchdown pass to Lance Moore in the corner of the end zone, a play that was challenged by Baltimore but not overturned.

The Ravens managed to get ahead with a Billy Cundiff field goal with 10:03 remaining 27–24.The Saints had the ball in the final minutes backed up near their own end zone when Drew Brees threw an interception to Cory Redding to give Baltimore a chance to run off the clock.

The Ravens cushioned their lead early in the third quarter with Flacco getting a 22-yard TD pass to WR Derrick Mason, making the score 20–10, as it would conclude.

The lead was narrowed with QB Carson Palmer throwing an 11-yard TD pass to WR Jerome Simpson, but the Ravens held on for the win, closing out the regular season with a 12–4 record.

After winning the coin toss and electing to defer, Carson Palmer threw an early interception to Ed Reed, giving the Ravens possession.

In the third quarter, the Ravens recovered a fumble from deep within Bengals territory, leading to a Ray Rice touchdown run, making the score 13–0.

The Bengals' final chance came with no timeout and 45 seconds from deep within their own territory, when they were able to play hurry-up offense and drive the ball to within a few yards of the end zone.

The Ravens regained the lead in the second quarter as quarterback Joe Flacco found running back Ray Rice on a 9-yard touchdown pass.

Baltimore added onto their lead in the third quarter with a pair of 29-yard field goals from Cundiff, followed by Flacco connecting with wide receiver Anquan Boldin on a 4-yard touchdown pass.