[2] The next day started with sightseeing; a visit to Vatican City, including St. Peter's Basilica, and the Sistine Chapel.

Incoming freshman Kaleena Mosqueda-Lewis had a stretch where she sank five consecutive three-point attempts, which extended a lead to 32 points by the end of the third quarter.

Five players scored in double figures, including Kaleena Mosqueda-Lewis, Tiffany Hayes, Bria Hartley, Briana Banks, and Heather Buck.

Although Dixon was not a starter, she averaged almost 22 minutes per game, sixth most among all players, and played a major role in the NCAA semi-final win over Georgetown.

Connecticut's incoming class of freshman included three players: Kaleena Mosqueda-Lewis, Brianna Banks, and Kiah Stokes.

The game featured the return of Caroline Doty, who missed the entire previous season due to injury.

Hayes 30 points was a career high, helping the Huskies to a 90–34 victory over the Buffalo in the second game of the World Vision Classic.

[21] Bria Hartley scored 24 points on nine for twelve shooting to help the Huskies defeat Towson University 92–31 November 30 in a game at the Veterans Memorial Coliseum in Hartford.

Connecticut held the defending National Champions to just over 32% field goal shooting, leading A&M coach Gary Blair to comment, "We're not ready for this kind of competition".

By comparison, the second longest streak is held by Duke University, who have won 142 games without consecutive losses.

[26] The Fairfield Stags entered the game against UConn on a four-game winning streak, but lost 93–40, representing the largest margin of defeat in a decade.

The game against North Carolina was held on Martin Luther King day, and has been an annual occurrence for many years.

After two free throws by Seton Hall, the huskies reeled off ten more points before giving up their first basket.

The game was close throughout, with UConn holding a slim two-point lead in the final minute, but Notre Dame forced overtime, and out scored the Huskies by seven points in the extra period, to win 74–67.

Villanova got with five points in the second half, but the Huskies responded with a 17–5 run, helping them to a comfortable margin, and a 72–49 victory.

[33] UConn returned to conference play with their match up against Cincinnati, coached by Jamelle Elliott, former long-time assistant at Connecticut.

Although the Bearcats had started the season with six straight victories, they were now playing tougher competition, and had lost eight of their last eleven games.

Dayeesha Hollins scored the first 13 points for Cincinnati, and was single-handedly keeping the game in reach, but UConn pulled away, and won easily 80–37.

[37][38] UConn next faced Rutgers, who were playing without star player Khadijah Rushdan, who was sitting out recovering from a concussion.

[39][40] The next game pitted UConn against a Louisville team with a twelve-game home winning streak, who bought 16,418 fans to the arena.

The team outscored the Cardinals 24–9 in the last twelve minutes of the first half, opening up a lead that stretched to more than 20 at one point.

However, the Cardinals fought back in the second half, at one time cutting the lead to six, but held on and won with a final score of 56–46.

Notre Dame had only one loss in Big East play, but in the rematch, handled West Virginia easily, winning by a margin of 28 points, 73–45.

[50] Connecticut, which had lost to St. Johns a week earlier, ending a 99-game home win streak, beat the Red Storm by 31 points, 74–43.

In the rematch, Connecticut opened up a ten-point lead in the first half, but Notre Dame responded, and cut the margin to a single point at halftime.

However, UConn went on a run, helped by two three-pointers from Kelly Faris and 19 points from Mosqueda -Lewis, and went on to win the 2012 Big East tournament championship 63–54.

[57][58][59] Connecticut opened with a 9–0 run, but Kentucky did not quit, and responded, first closing the gap, then taking a small lead.

In the second half, the Huskies expanded the margin to 20 points, then ended with a 15-point victory, 80–65, to propel the UConn team to their fifth consecutive Final Four, tying an NCAA record.

Notre dame had a four-point lead with two minutes to go when Kelly Faris hit a layup to cut the margin to two, then sank two free throws to tie it with 44 seconds to go, then stole the ball and sank two more free throws to give UConn a two-point lead at the 11 second mark.

Skyler Diggins missed a jump shot, but Natalie Novasel grabbed the rebound and hit a layup to send the game to overtime.