The Huskies, led by Hall of Fame head coach Geno Auriemma in his 38th season at UConn, split their home games between Harry A. Gampel Pavilion on their campus in Storrs and the XL Center in Hartford, Connecticut.

[a] The Huskies finished an injury-plagued previous season with a record of 30–6, losing the championship game of the 2022 NCAA women's basketball tournament to South Carolina.

Three graduates from that squad were selected in the 2022 WNBA draft, but with six returning starters including the backcourt of Paige Bueckers, Azzi Fudd, and Nika Mühl, with forwards Dorka Juhász, Aaliyah Edwards, and Caroline Ducharme, UConn was expected to win the much improved Big East again.

[2] Starting the season already down two players, UConn played surprisingly well against early opponents, with strong wins against #3 Texas, #10 NC State, and #9 Iowa in the first weeks.

Fudd was injured in the loss to #7 Notre Dame, and by the end of December the Huskies only had seven players healthy, even after Juhász's return.

In early February the team matched up against the #1 ranked South Carolina Gamecocks with a sold-out home crowd in the XL Center, but lost 77–81.

Three days later, Marquette upset the noticeably worn-out Huskies in a tight defensive battle, UConn's first consecutive loss in 30 years.

While UConn was able to twice defeat rival Villanova, several Big East teams strongly tested the still-shorthanded and battered Huskies, St. John's outscoring them by five.

The Huskies graduated senior starters Christyn Williams, Olivia Nelson-Ododa, and Evina Westbrook from the 2021–22 roster, each of them being drafted into the Women's National Basketball Association.

On August 1, superstar guard Paige Bueckers tore her left ACL during a pick-up game, and UConn announced two days later that she would miss the entire 2022–23 season.

[11][12] Roster Last update: March 11, 2023 The Huskies began the season by hosting the Kutztown Golden Bears in an exhibition contest, the first meeting between the two schools.

"[13] In the November 6, 2022 exhibition at the XL Center, the Golden Bears briefly led 7–6 at the start, but the Huskies quickly took over, taking a 30 point lead into halftime.

[16][17] An early season home contest against a top ten opponent is always highly anticipated, but the second game against number three Texas was a rematch for Husky graduate transfer Lou Lopez Sénéchal.

After a loss in NCAA tournament play against Texas ended her four-year career at Fairfield University, Lopez Sénéchal found herself with an extra year of eligibility (due to COVID) and through the transfer portal arrived in Storrs.

The two teams clashed in the previous season's NCAA tournament regional final, dubbed a "double overtime thriller" by Sports Illustrated.

Inês Bettencourt was a freshman to-be headed to a Florida junior college when Paige Bueckers was injured during the summer, and UConn hastily looked for additional guard help.

[44][45] UConn returned Juhász and Mühl to the starting lineup, but minutes before the tip off, the school announced that head coach Auriemma would not be available due to illness.

[52][53][54] Eight players dressed for Marquette once DeBerry rejoined the team, but fans held their collective breaths when Juhász has knocked to the ground and had to be helped to the sideline.

Auriemma traveled with the team and attended the morning shootaround but was not feeling well and decided to sit out the evening game, so Dailey took over again as head coach.

Fans anxious for Fudd's return were encouraged when photos of her in the afternoon shootaround emerged with her wearing braids, a hairstyle she reserves for game days.

After Villanova's leading scorer Maddy Siegrist hit an opening three pointer, the Huskies responded with nine consecutive points.

UConn responded with a 13–2 run to extend their lead to 17, but the Friars cut it back to single digits with just over three minutes to go.

Georgetown cut the margin to four with half a minute left in the game but UConn hit their final four free throws to get the 67–59 win.

[84][85] In front of a sold-out crowd, the Huskies played the Blue Jays almost even in the first quarter, then gradually opened up a nine point lead with 3 1/2 minutes to go in the half.

That was as close as Villanova would get, with Lopez Sénéchal scoring a "crucial rainbow jumper late in the fourth quarter" to lead the Huskies to a 60–51 win.

The Huskies came out in the second half with suffocating defense, holding the Red Storm scoreless for almost six minutes, taking a modest 43–35 lead.

DePaul's best player, Aneesah Morrow, who had 25 points in the game, had the ball and raced down the court in an attempt to take the lead but was tied up, and the possession went to UConn.

The Huskies hit two free throws, and DePaul missed a three point jumper at the buzzer, giving UConn a 72–69 win.

The Bears had come back from an 18 point deficit to beat Alabama in the first round, connecting with a school record 14 three-pointers in that game.

The Huskies responded in the second quarter, taking a five-point lead into the half on a Mühl buzzer beating three taken from half-court.