The Huskies, led by Hall of Fame head coach Geno Auriemma in his 39th season at UConn, split their home games between Harry A. Gampel Pavilion on their campus in Storrs, and the XL Center in Hartford.

However, led by All-Americans Paige Bueckers and Aaliyah Edwards, the Huskies went undefeated in the Big East and then won the conference tournament.

The 2022–23 UConn Huskies began with season-ending injuries to All-American junior guard Paige Bueckers and freshman forward Ice Brady.

Mühl ranked second among all NCAA women in assists during the season, UConn relying on her high energy and court vision to make Husky touches in the paint quick and decisive.

With a light bench, Edwards, Mühl, Juhász, Lopez Sénéchal, and Griffin became a durable quintet in January; when Fudd and Ducharme returned, the team quickly improved.

The Huskies graduated senior starters Dorka Juhász and Lou Lopez Sénéchal from the 2022–23 roster, and both were drafted into the Women's National Basketball Association.

Freshman center Jana El Alfy suffered an achilles injury in August while playing for the Egyptian national U19 team and later underwent corrective surgery.

[6][7] Tonya Cardoza, another former Huskies assistant, returned to UConn in June after serving as Temple's head coach for 15 years.

[8] Also in June, UConn announced Ben Kantor was promoted to assistant coach from his previous staff position serving as the team's video coordinator since 2015.

[9] Even after graduating two WNBA draftees, the Huskies entered the season with six reliable and tested starters, led by seniors Nika Mühl, Aubrey Griffin, and 2023 All-American Aaliyah Edwards.

The Huskies then went on a 13-game winning streak as they started their Big East schedule, though they became even more shorthanded when Griffin experienced an ACL tear in her left knee during the Creighton game on January 3.

In the Final Four, the Caitlin Clark-led Iowa Hawkeyes defeated the Huskies; the game was watched by a college basketball record 14.4 million viewers on ESPN.