The 2013 season was the Buffalo Bills' 44th in the National Football League (NFL) and their first under head coach Doug Marrone.

It was also their final season under the ownership of Ralph Wilson, who died in March 2014 at the age of 95.

This was the first year of renewed leases on Ralph Wilson Stadium and for the Bills Toronto Series, both of which were signed in the preceding offseason.

Stephen Gostkowski kicked a 35-yard field goal with five seconds left to give the Patriots the win.

Buffalo trailed for most of their Week 2 game against the Panthers but took the lead with two seconds left after Stevie Johnson caught a 2-yard touchdown pass from EJ Manuel.

Dan Carpenter kicked the extra point to give the Bills a 24–23 win.

EJ Manuel left the game for the Bills with a knee injury, and was replaced by Jeff Tuel.

The Bills had a 24–17 lead in the third quarter, but the Browns, who also lost quarterback Brian Hoyer, won the game with Brandon Weeden at the helm.

The Bills trailed 24–10 in the fourth quarter, but came back to tie the game after Marquise Goodwin caught a 40-yard touchdown pass from Thad Lewis and force overtime.

The Bengals returned the punt 39 yards to set them up in field goal range.

A couple of plays later, Mike Nugent kicked the game winning 43-yard field goal.