The 2015–16 North Florida Ospreys women's basketball team represented the University of North Florida in the 2015–16 NCAA Division I women's basketball season.

The Ospreys, led by first year head coach Darrick Gibbs, play their games at UNF Arena and were members of the Atlantic Sun Conference.

They finished the season 7–23, 3–11 in A-Sun play to finish in sixth place.

They lost in the quarterfinals of A-Sun Tournament to USC Upstate.

All home games and conference road games were shown on ESPN3 or A-Sun.TV.