The best six teams of the 2015 Campeonato Brasileiro Série A eliminated until the third round qualified for the 2016 Copa Sudamericana.

The competition was a single elimination knockout tournament featuring two-legged ties.

That division made sure that each team within a pair would not face each other before the finals as they would be placed in opposite sides of the bracket.

The following stages had additional draws to determine the order of the matches as the tournament advanced.

All draws will be held at CBF headquarters in Rio de Janeiro.