The 2016 Copa Libertadores second stage was played from 16 February to 21 April 2016.
[2] The draw of the tournament was held on 22 December 2015, 20:30 PYST (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.
The defending champions (River Plate) were automatically placed first in Pot 1 and allocated to Group 1 for the draw.
The remaining teams were seeded based on their CONMEBOL ranking (shown in parentheses).
The fixture list was determined by the draw as follows:[9] The matches were played on 16–18, 23–25 February, 1–3, 8–10, 15–17 March, 5–7, 12–14 and 19–21 April 2016.