The 2019 African Women's Handball Champions League was the 41st edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament was held from October 4–13, 2019 at the Pavilhão Vavá Duarte and Pavilhão Craveiro Lopes in Praia, Cape Verde, contested by 8 teams and won by Clube Desportivo Primeiro de Agosto of Angola.

[1] Bandama

FAP Yaoundé HC Héritage Primeiro de Agosto ABO Sport Atlético do Mindelo Petro Atlético [2] * Note:   Advance to semi-finals * Note:   Advance to quarter-finals

* Note:   Advance to quarter-finals