The 2021 African Handball Cup Winners' Cup was the 26th edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament was held from 24 August till 2 September 2021 and took place in Meknes, Morocco, contested by 8 teams and won by Al Ahly SC of Egypt.

[1] Al Ahly SC Red Star FAP Yaoundé Rima Sokoto HC Widad Smara Inter Club JS Kinshasa

[2] * Note:   Advance to quarter-finals * Note:   Advance to quarter-finals