The 2022 African Handball Champions League is the 43rd edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament will be held from the 30 September to 9 October 2022 in Hammamet and Nabeul in Tunisia.

[1] The draw took place on 30 August 2022 in Kigali (Rwanda).

[2] Club Africain Zamalek SC FAP Yaoundé Red Star MC Alger Al Ahly SC ES Tunis HC JS Kinshasa Flowers HBC ES Ain Touta [3][4][5]