The 2010 African Handball Champions League was the 32nd edition, organized by the African Handball Confederation, under the auspices of the International Handball Federation, the handball sport governing body.

The tournament was held from October 22–30, 2010 at the Complexe Sportif Mohammed V in Casablanca, Morocco, contested by 10 teams and won by Atlético Petróleos de Luanda of Angola.

[1] HC Héritage Inter Club Petro de Luanda Phoenix Gabon US Nouasseur ASF Sahel FAP Yaoundé Rombo Sport Saltigue HC Vainqueur [2] * Note:   Advance to quarter-finals   Relegated to 9th place classification

* Note:   Advance to quarter-finals   Relegated to 9th place classification** Penalty for failing to pay participation fees [3][4]