The 2019 season was the Arizona Cardinals' 100th in the National Football League (NFL), their 32nd in Arizona and their first under head coach Kliff Kingsbury, following the firing of former head coach Steve Wilks the previous season.

The Cardinals were one of two current teams, along with the Chicago Bears, who were among the 14 charter members of the American Professional Football Association, which later became the NFL, that celebrated its 100th season in 2019.

However, they were mathematically eliminated from playoff contention for the fourth straight season after a Week 13 loss to the Los Angeles Rams.

[3] Roster changes In addition to receiving the number one overall draft pick, the Cardinals also have the top spot on the waiver wire by virtue of having the worst record in the NFL during the 2018 season.

Front office Head coaches Offensive coaches Special teams coaches Strength and conditioning Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve Note: Intra-division opponents are in bold text.