Despite starting the season at 3–0 the Rams lost 7 of their final 13 games and after a loss to their NFC West rival San Francisco 49ers in Week 16, were eliminated from playoff contention for the first time since 2016.

Notes Following the 2019 NFL draft, the Rams signed 19 undrafted rookie free agents who would compete for roster spots and participate in the team's offseason and training camp programs.

Linebacker Samson Ebukam deflected a lateral attempt by Panthers quarterback Cam Newton and recovered the fumble, which helped set up a 5-yard touchdown run by Brown and a 10-0 Rams lead.

Another new Ram, safety Eric Weddle, was taken out of the game in the second quarter following a collision with Panthers running back Christian McCaffrey that resulted in a head laceration.

Playing their home opener at the renovated Los Angeles Memorial Coliseum for the final time, the Rams hosted the Saints in a rematch of the 2018 NFC Championship Game and came away with a convincing victory.

Three rushes for 16 yards by running back Malcolm Brown put the Rams on the 2-yard line and quarterback Jared Goff connected with wide receiver Brandin Cooks for the score.

Strong safety John Johnson added four tackles and an interception of Saints quarterback Drew Brees, who left the game in the first quarter with a hand injury and did not return.

Safety John Johnson's end zone interception of Browns quarterback Baker Mayfield with 27 seconds remaining capped a successful goal line stand as the Rams improved to 3–0 with their first win on Sunday Night Football in 14 years.

The Rams won a Sunday Night game for the first time since a 20–10 victory over the Dallas Cowboys that was played on January 1, 2006, the final week of the 2005 NFL season.

Jared Goff set personal bests for passing attempts, completions, and yards, but also had four turnovers (all of which led directly to Tampa Bay touchdowns) as the Rams lost for the first time in the season.

In addition to his new team records for single game attempts and completions, which broke marks previously held by Marc Bulger (vs. New York Giants, 2005), Goff's 517 passing yards tied with Tom Brady (New England vs. Miami, 2011) for the eighth-highest single-game total in NFL records, and was exceeded only by Norm Van Brocklin's league-record 554 yards against the New York Yanks in 1951 for the highest total in team history.

However, Goff threw three interceptions and then fumbled once with just over a minute remaining when he was sacked and stripped of the ball by Buccaneers linebacker Shaquil Barrett, with defensive tackle Ndamukong Suh picking it up and running it 37 yards for the touchdown to seal the victory against his former team.

Safety Eric Weddle had 15 tackles to lead the Rams, and cornerback Marcus Peters picked off a Jameis Winston pass and returned it 32 yards for a touchdown in the fourth quarter.

A critical turnover broke open a tie game in the second half as the 49ers shut down the Rams' offense in a key NFC West battle at the Coliseum.

Kicker Greg Zuerlein had three field goals, while punter Johnny Hekker connected on a 23-yard pass to Nick Scott on a fake punt to help set up a Rams score.

Kupp, who had five catches for 165 yards in the first half alone, scored on a wild double-reverse flea-flicker play midway through the second quarter in which he took a handoff from quarterback Jared Goff going right, then handed the ball to fellow wide receiver Robert Woods going left, who then tossed it back to a waiting Goff, who found Kupp breaking free down the right sideline for the touchdown that put the Rams ahead for good.

The game also marked a significant milestone for Rams offensive tackle Andrew Whitworth, a 14-year NFL veteran who spent his first 11 seasons playing for the Bengals.

Linebacker Dante Fowler gave Los Angeles a 7–0 lead just 14 seconds into the game when a shotgun snap went over Steelers quarterback Mason Rudolph's head.

Early in the fourth quarter, the Rams pulled to within 14-12 when defensive tackle Aaron Donald (making his first appearance as a pro in Pittsburgh, where he played his high school and college football) sacked Rudolph in the end zone for a safety.

Todd Gurley matched his season-high with 97 rushing yards on 25 carries, including a 1-yard touchdown run late in the first half as the Rams bounced back with a victory over the Bears before a Sunday Night Football audience.

In front of a nationwide audience on Monday Night Football, the Rams suffered the worst home loss in franchise history as the visiting Ravens dominated all phases of the game.

Under constant pressure throughout the game, Murray rushed a pass that was picked off by rookie safety Taylor Rapp, who returned his first career interception 31 yards for a touchdown and a 34-7 Rams lead.

Playing again at home in front of a national TV audience for the third time in four weeks, the Rams boosted their record to 8–5 with a strong Sunday Night Football win over the visiting Seahawks.

After giving up a field goal to Seattle, the Rams took the lead for good on Malcolm Brown's 1-yard touchdown run with just over five minutes left in the first quarter, capping off an 8-play, 75-yard drive.

The Rams offense sputtered in the third period as Goff threw interceptions on his team's first two drives, including one returned 55 yards by safety Quandre Diggs for a Seattle touchdown.

Taking on the NFC's top team, the Rams battled the 49ers in a wild showdown, but critical errors in the final minute of both halves doomed Los Angeles, which was eliminated from the playoff race with the loss.

Gurley scored again on a 1-yard run midway through the second period, giving him 58 rushing touchdowns for his career, tying him with Hall of Fame predecessor Marshall Faulk for the most in Rams franchise history.

With a 21–10 lead, the Rams seemed poised for an upset, but after the defense gave up a touchdown run to Raheem Mostert, Goff threw an interception to 49er linebacker Fred Warner, who ran untouched 46 yards to put San Francisco in front 24-21 just 46 seconds before halftime.

Defensively, Rams' linebacker Dante Fowler had 2.5 sacks and Jalen Ramsey added an interception, but a miscommunication between him and rookie safety Taylor Rapp led to a blown coverage that gave the 49ers their final scoring opportunity.

The Rams avoided the mistakes that had plagued them the entire season to end 2019 with a victory in the team's final game played at the Los Angeles Memorial Coliseum.