The 2019 season was the Detroit Lions' 90th in the National Football League (NFL) and their second year under head coach Matt Patricia.

After franchise quarterback Matthew Stafford broke his backbone in a Week 9 loss to the Oakland Raiders, the Lions were forced to turn to former Cincinnati Bengals backup quarterback Jeff Driskel and later undrafted free agent David Blough, neither of whom was able to lead the Lions to a single win.

Arizona responded with a 20-yard field goal by Zane Gonzalez to make the score 17–3 in favor of Detroit at half-time.

The Chargers extended their lead in the second quarter via a 39-yard field goal by Ty Long, making the score 10–6 in favor of Los Angeles at half-time.

After a scoreless third quarter, Detroit scored the only points of the second half via a 31-yard touchdown pass from Stafford to Kenny Golladay to take a 13–10 lead.

The Chargers' attempted comeback failed when a Philip Rivers pass was intercepted by Darius Slay in the end zone with 1:03 to play in the game, giving the Lions their first win of the season.

The Lions added 13 points in the second quarter via a one-yard touchdown run from Kerryon Johnson and a pair of field goals by Matt Prater, from 25 and 33 yards, respectively, making the score 20–10 in favor of Detroit at half-time.

The Lions extended their lead in the fourth quarter via a 12-yard touchdown pass from Matthew Stafford to Marvin Jones.

The Lions opened the scoring in the first quarter via a 25-yard field goal by Matt Prater, before extending their lead through a five-yard touchdown pass from Matthew Stafford to T. J. Hockenson.

The Lions responded with 10 points via a 53-yard field goal by Prater and a nine-yard touchdown pass from Stafford to Kenny Golladay to regain the lead.

The Packers responded with 10 points via a five-yard touchdown pass from Aaron Rodgers to Jamaal Williams and a 37-yard field goal by Mason Crosby, making the score 13–10 in favor of Detroit at half-time.

The Packers responded with 10 points via a 35-yard touchdown pass from Rodgers to Allen Lazard, and a 23-yard field goal by Crosby as time expired, making the final score 23–22 in favor of Green Bay.

The Lions responded with a two-yard touchdown pass from Stafford to Jones, making the final score 42–30 in favor of Minnesota, for Detroit's third consecutive loss.

The Lions scored 14 points in the first quarter via a 13-yard fumble return by Devon Kennard and a 49-yard touchdown pass from Matthew Stafford to Marvin Hall.

The Bears responded with an 18-yard touchdown pass from Mitchell Trubisky to Ben Braunecker, making the score 7–6 in favor of Chicago at half-time.

In week 11, the Lions hosted the Dallas Cowboys wearing white jerseys at a home game for the first time since 1970.

Washington responded with 10 points via a 91-yard kickoff return by Steven Sims and a 37-yard field goal by Hopkins to regain the lead.

The Lions added a 49-yard field goal by Prater at the end of the first half, making the score 13–6 in favor of Washington at half-time.

The Lions scored the only points of the third quarter via a 12-yard touchdown pass from Jeff Driskel to Logan Thomas to tie the game.

The Redskins responded with two field goals by Hopkins, from 42-yards, and 39-yards, respectively, making the final score 19–16 in favor of Washington, for Detroit's fourth consecutive loss.

In week 13, the Lions hosted a rematch with their divisional rival, the Chicago Bears, in their annual Thanksgiving Day game.

The Lions responded with 14 points when third-string quarterback David Blough, in his NFL debut, threw two touchdown passes, one from 75-yards out to Kenny Golladay and one from eight-yards out to Marvin Jones.

The Vikings added 10 points in the second quarter via a 27-yard field goal by Dan Bailey and a three-yard touchdown run from Dalvin Cook, making the score 17–0 in favor of Minnesota at half-time.

The Lions finally got on the board via a 44-yard field goal by Matt Prater, making the score 21–3 in favor of Tampa Bay at half-time.

In the fourth quarter the Lions added a one-yard touchdown run from Hills, reducing the Buccaneers lead to seven points.

The Lions attempted comeback failed when David Blough's pass was intercepted by Sean Murphy-Bunting and returned 70-yards for a touchdown.

The Buccaneers extended their lead via a 25-yard touchdown pass from Winston to Perriman, making the final score 38–17 in favor of Tampa Bay, for Detroit's seventh consecutive loss.

The Broncos responded with 10 points via a one-yard touchdown run from Royce Freeman and a 34-yard field goal by Brandon McManus, tying the score at 10–10 at halftime.

The Lions responded with a 42-yard field goal by Matt Prater as time expired, making the score 17–3 in favor of Detroit at half-time.

The Packers responded with 10 points via a 28-yard touchdown pass from Rodgers to Allen Lazard to tie the game, and a 33-yard field goal by Crosby as time expired, making the final score 23–20 in favor of Green Bay, for Detroit's ninth consecutive loss.