[1] During the season they equaled the franchise record nine-game losing streak of the 1976 Giants,[2] predominantly due to ball security issues and poor defensive play.

The offseason saw some major changes to the Giants roster, with star wide receiver Odell Beckham Jr. and veteran linebacker Olivier Vernon being traded to the Cleveland Browns, and Pro Bowl safety Landon Collins being lost to the Washington Redskins during free agency.

After suffering defeats in the opening two games of the regular season the Giants made a change at quarterback, with veteran Eli Manning being benched in favor of first-round draft selection Daniel Jones.

During the offseason the Giants made several controversial changes to their roster, headlined by the trade of star wide receiver Odell Beckham Jr. to the Cleveland Browns.

The trade also sent veteran linebacker Olivier Vernon to the Browns, with the Giants receiving safety Jabrill Peppers and guard Kevin Zeitler in return, in addition to Cleveland's first-round and third-round picks in the 2019 NFL draft.

[3] Several other starters were lost during free agency, including Pro Bowl safety Landon Collins who ultimately signed a six-year, $84 million contract with division rivals, the Washington Redskins.

[5] The biggest signing of free agency was Golden Tate, who joined on a four-year, $37.5 million contract from the Detroit Lions; he would ultimately be suspended for the first four games of the regular season for violating the league's performance-enhancing drugs policy.

With those picks, they selected Duke quarterback Daniel Jones at number 6, Clemson defensive tackle Dexter Lawrence at 17, and Georgia cornerback Deandre Baker at 30.

[9] Jones threw for two touchdowns and rushed for two more as he led the Giants to victory, overcoming an 18-point deficit at half time and having lost star running back Saquon Barkley to injury in the second quarter.

[16] Further injury problems affected the team with starting wide receiver Sterling Shepard suffering from ongoing concussion symptoms that could be potentially career threatening.

[20] On his return Manning led the Giants to a healthy 17–3 halftime lead, linking up with rookie wide receiver Darius Slayton for two touchdowns, but he was unable to get the offense moving at all in the second half as the Eagles scored 14 unanswered points before snatching victory in overtime.

[2] After calling a fan a "retard" on Twitter on the Wednesday following the game, and later failing to satisfactorily apologize, Jenkins was waived with an injury designation on December 13, 2019;[21][22] he was claimed off waivers by the New Orleans Saints.

[23] With Jones remaining on the sidelines in week 15, Manning continued as the starter as the Giants finally snapped their nine-game losing streak by defeating the Miami Dolphins 36–20.

On December 30, 2019, the day after a 34–17 loss to the Philadelphia Eagles in Week 17 left the team with a losing 4–12 record for the season, head coach Pat Shurmur was fired.

[42] Having been cut as the roster was trimmed to the 53-man limit on August 31, Reggie White, Jr., Jon Hilliman, C. J. Conrad, Josiah Tauaefa, Jake Carlock, Evan Brown, Freedom Akinmoladun and Chris Slayton were resigned to the practice squad alongside new signings Corn Elder and David Sills V.[85] On September 18, 2019, Conrad was released and running back Austin Walter was signed to replace him.

[69] With backup running back Wayne Gallman joining Barkley on the sidelines, Walter was signed to the active roster on October 10, prior to the week 6 matchup against New England.

[77] Later that day, White and Akinmoladun were released and the open spots on the practice squad were filled by tight end Garrett Dickerson, wide receiver Alex Bachman and long-snapper Colin Holba.

On December 5, the Giants signed rookie center Tanner Volson,[95] and ex-Panthers safety Rashaan Gaulden to the fill the vacant spots on the practice squad.

The Giants offense could not keep up, as some questionable play call decisions by head coach Pat Shurmur took more potential points off the board.

With their first win of the 2019 season, the Giants improved to 1–2,[10][11] though star running back Saquon Barkley left the game after spraining his ankle.

Second year linebacker Lorenzo Carter stripped Tom Brady which the Giants scored on the ensuing fumble tying the game 14–14.

Both teams showed off stout defensive play as both offenses struggled to gain any traction moving the ball through the first 3 quarters until the Patriots broke through in the 4th and iced the game 35–14.

Despite Saquon Barkley returning from injury, the Giants quickly fell in a 17–0 deficit which proved to be too much to overcome despite clawing back in the game.

Daniel Jones threw 4 touchdown passes for the first time in his career, but had a key fumble in the 2nd quarter which former Giant Devon Kennard scored on.

This game is famous for being interrupted by a stray black cat in the 2nd quarter, which the media pointed out put a hex on both the Giants and the Cowboys.

After the teams traded field goals, Manning would throw another touchdown pass to Slayton, this time from 55 yards, to build the Giants' lead to 17–3 before halftime.

Because Joe Burrow was a shoo-in to be drafted 1st overall to the Cincinnati Bengals, this was informally known as the Chase Young Bowl as both the Giants and Redskins were still in the running to pick 2nd.

With Daniel Jones back in the lineup for New York, the Giants withstood a late rally by the rival Redskins and improved to 4–11 with the overtime victory.

Daniel Jones became the first rookie quarterback in NFL history to throw for 300 yards, 5 touchdowns, and no turnovers in a single game.