The 2019 season was the Tampa Bay Buccaneers' 44th in the National Football League (NFL), their sixth under the leadership of general manager Jason Licht, their 22nd playing their home games at Raymond James Stadium and their first under head coach Bruce Arians.

Quarterback Jameis Winston threw three interceptions, two returned for a touchdown, as Tampa Bay lost on opening day to San Francisco.

Rookie kicker Matt Gay's field goal attempt sailed wide right as time expired and the Giants held on to win.

The Bucs set a franchise record for points scored with 55 in a win against the defending NFC champions.

Shaquil Barrett continued his run for Defensive Player of the Year by getting an interception, a sack and forcing the fumble that ended the game.

Teddy Bridgewater threw for 314 yards and four touchdown passes, as New Orleans defeated Tampa Bay 31–24.

Nose tackle Vita Vea became the heaviest man in NFL history to catch a touchdown pass at 347 pounds.

Running back Peyton Barber had 2 rushing touchdowns as the Buccaneers' defense continued their strong level of play for the second consecutive week, sacking quarterbacks Nick Foles and Gardner Minshew a combined 5 times, intercepting 2 passes, forcing 3 fumbles, and recovering 2 of them with 1 returned for a touchdown by Devin White.

The Buccaneers overcame 4 turnovers and a 14 point deficit to defeat the Colts 38-35 en route to their first 3-game winning streak since 2016.

Despite the win, which improved the team to 6–7, Tampa Bay was eliminated from postseason contention when the Minnesota Vikings also won that day.

Jameis Winston became the first player in NFL history to have consecutive games of 450 yards passing as he threw for a career best 458 yards, 4 touchdowns, and 1 interception en route to breaking the franchise record for touchdown passes in a season that he set in 2016 with his 30th and the Buccaneers won their 4th straight game.

Atlanta's Younghoe Koo kicked a 33-yard field goal as time expired in regulation, sending the game to overtime.