On opening day, Detroit Tigers starting pitcher Jordan Zimmermann pitched a perfect game through 6 2/3 innings against the Blue Jays before giving up a hit to Teoscar Hernández.
[39] In the final game of the series, Indians pitcher Mike Clevinger pitched five innings, while giving up one hit and striking out 10 Blue Jays batters in a 3–1 Cleveland win.
[48] On August 11, Masahiro Tanaka of the New York Yankees pitched eight innings against the Blue Jays while giving up only three hits in a 1–0 win that split a four-game set between the two teams.
[49] Aroldis Chapman came in the 9th inning to close the game for the Yankees, inducing a double play from the bat of Vladimir Guerrero Jr. following a 13-pitch at-bat, for which the rookie received a standing ovation from the crowd at Rogers Centre.
[52] On September 1, Justin Verlander of the Houston Astros pitched a no-hitter against the Blue Jays, the third of his career (and second against Toronto) in a 2–0 win.