2020–21 Michigan State Spartans women's basketball team

The Spartans, led by fourteenth year head coach Suzy Merchant, played their home games at the Breslin Center in East Lansing, Michigan as members of the Big Ten Conference.

As the seventh seed in the Big Ten tournament they defeated Penn State in the Second Round and Indiana in the Quarterfinals before losing to Iowa in the Semifinals.

They received and at-large bid to the NCAA tournament where they were the ten seed in the Mercado Regional.

They lost in the first round to seven seed Iowa State to end their season.

They did not get a chance for further post season play, as the NCAA women's basketball tournament and WNIT were cancelled before they began due to the COVID-19 pandemic.